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PNPLA3 Rabbit pAb (bs-12745R)  
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產品編號 bs-12745R
英文名稱 PNPLA3 Rabbit pAb
中文名稱 脂肪營養素PNPLA3抗體
別    名 Acylglycerol O acyltransferase; Adiponutrin; ADPN; C22orf20; Calcium independent phospholipase A2 epsilon; DJ796I17.1; iPLA(2)epsilon; IPLA2-epsilon; Patatin like phospholipase domain containing 3; patatin like phospholipase domain containing protein 3; phospholipase A2, calcium independent, epsilon.  
研究領域 腫瘤  心血管  細胞生物  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PNPLA3: 101-200/481 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

Function:
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.

Subcellular Location:
Membrane; Single pass type II membrane protein.

DISEASE:
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease description:A condition characterized by accumulation of triglycerides in the liver. It is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries.

Similarity:
Contains 1 patatin domain.

SWISS:
Q9NST1

Gene ID:
80339

Database links:

Entrez Gene: 609368 Dog

Entrez Gene: 101131854 Gorilla

Entrez Gene: 101824852 Hamster

Entrez Gene: 80339 Human

Entrez Gene: 100406659 Marmoset (common)

Entrez Gene: 116939 Mouse

Entrez Gene: 100344884 Rabbit

Entrez Gene: 362972 Rat

Omim: 609567 Human

SwissProt: Q9NST1 Human

SwissProt: Q91WW7 Mouse

Unigene: 654800 Human

Unigene: 390817 Mouse

Unigene: 97779 Rat



產品圖片
Sample: HepG2(Human) Cell Lysate at 30 ug Primary: Anti-PNPLA3 (bs-12745R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53/58 kD
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